5-lipoxygenase (5-LOX) is an enzyme that transforms fatty acids into leukotrienes.1 Since 5-LOX levels increase over time, excess 5-LOX has been linked to some of the common effects of normal aging.2
Boswellia extract inhibits 5-LOX
The Indian plant Boswellia serrata contains compounds shown to inhibit 5-LOX to support joint and arterial health. Boswellia inhibits 5-LOX at the cellular level. Scientific data reveals that a compound in boswellia called AKBA (3-O-acetyl-11-keto-ß-boswellic acid) is the key to this beneficial action.3
But boswellia compounds are poorly absorbed into the blood. For this reason, we’ve used AprèsFlex®, a standardized form of boswellia extract. AprèsFlex® absorbs into the blood 52% more than previously available boswellia extracts.
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Dietary factors increase 5-LOX prevalence
The typical American diet adds to 5-LOX levels. Foods rich in omega-6 fatty acids like red meat, poultry, eggs and dairy products, along with high-glycemic carbohydrates, trigger production of arachidonic acid. The body produces 5-LOX enzyme in response to arachidonic acid.1
Benefits of modulating 5-LOX
5-LOX creates compounds like leukotriene B4 out of arachidonic acid. Inhibiting leukotriene B4 helps support joint, arterial and tissue health.5 Inhibiting 5-LOX also helped support healthy cell division in preclinical models.6
Each 100 mg vegetarian capsule of 5-LOX Inhibitor with AprèsFlex® is standardized to provide 20% of active AKBA from boswellia. Most people need only one capsule a day.
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