Palmitoylethanolamide (PEA)
Palmitoylethanolamide (PEA) is a unique kind of fatty acid that can inhibit discomfort.3 Your body naturally produces PEA as part of a healthy inflammatory and immune response.4
In fact, PEA inhibits the secretion of compounds from mast cells, a
type of white blood cell. Over time, our mast cells decrease in number,
causing our remaining mast cells to work harder.5
That can make them overly sensitive, activating processes linked to
nerve discomfort. By inhibiting compounds released by mast cells, PEA
promotes your body’s natural response to uncomfortable nerve stimuli at
the cellular level.6-8
PEA’s efficacy has been demonstrated in multiple clinical trials.9
In a randomized controlled trial following 636 patients over a period
of three weeks, 600 mg of PEA every day significantly improved scores
that measured relative comfort and quality of life.10 In a
smaller randomized controlled trial, patients reported that PEA
outperformed standard care for discomfort when taken for two weeks.11
Honokiol
Honokiol is a naturally occurring lignan compound derived from
several species of magnolia, many of which have been used in
traditional Asian medicine for centuries.12 Now, scientists are discovering that honokiol has applications for nerve health and comfort.
Honokiol has been shown to support the “calming” GABA receptors in the brain, which in turn helps alleviate discomfort.13-15
Furthermore, honokiol is quickly taken up into the brain in animal
models, making it an ideal ingredient for nerve health and comfort.16,17
Innovative Daytime & Nighttime Formula
ComfortMAX™ has been formulated to be taken twice a day, one tablet
in the morning and one tablet at night, right before bed, for day and
night support. Each package of ComfortMAX™ provides a 30-day supply.