What Is GEROPROTECT Autophagy Renew?
As we age, our bodies get less adept at autophagy, the
process for recycling debris in our cells that get in the way of normal
function. Give that cellular recycling process a helping hand—so you can
live your longest, healthiest life. GEROPROTECT® Autophagy Renew
contains a plant flavonoid, luteolin, and an alkaloid from pepper called
piperlongumine, which support your body’s natural clean-up process.
Give your body’s natural cellular recycling process a boost—so you can live your longest, healthiest life.
GEROPROTECT® Autophagy Renew Benefits
- Innovative longevity formula
- Helps your body function optimally, without cellular debris getting in the way
- Promotes healthy AMPK activity
- Encourages cells to recycle waste material
- Helps maintain cellular energy balance
Recycling what’s inside: autophagy explained
We know that
recycling is good for the environment. But as it turns out, it’s also
good for our cells: autophagy is a natural process by which cells clean
up intra-cellular debris and other metabolic waste. Tiny cellular
organelles called lysosomes breakdown and repurpose this spent material.
So why does cellular autophagy matter? Because it helps our bodies
conserve energy and function properly, which is essential to living a
long, healthy life.
Without autophagy, the insides of our cells would become
cluttered and eventually cease to function. The problem is autophagy
naturally decreases over time. But the right nutrients can encourage
youthful, healthy autophagy at the cellular level—the hard part is
figuring out which nutrients do the best job.
Insilico Artificial Intelligence
GEROPROTECT® Autophagy Renew was created through a partnership with
Insilico Medicine, Inc., who used their database of studies on
geroprotectors to identify luteolin from Japanese sophora flower for its
ability to promote autophagy—effects that are also supported by several
We added piperlongumine (a pepper alkaloid) because of our own
extensive scientific review. Together, these nutrients have the
potential to encourage healthy cellular autophagy—and with it,
Luteolin is a flavonoid present in fruits, vegetables and nutritious
herbs. We get trace amounts of luteolin in our diets, but not nearly
enough to encourage healthy cellular renewal. GEROPROTECT® Autophagy
Renew contains 165 mg of luteolin per serving. In pre-clinical studies,
luteolin promoted autophagy, leading to a variety of health benefits,
particularly in the brain.1
Luteolin supports the cellular pathways that encourage autophagy, such as AMPK signaling.2 Luteolin also promotes the generation of new lysosomes, the "recycling plants" inside your cells that break down waste.2
Plus, luteolin inhibits the processes that discourage autophagy, such
as mTOR signaling—a central regulator of cellular metabolism and
Piperlongumine is a biologically active alkaloid found in pepper
plants. In pre-clinical studies, piperlongumine was shown to activate
autophagy as indicated by increased cellular markers called
LC3-autophagosomes, structures involved in initiation of autophagy
within a cell.3,4
Piperlongumine activates Beclin-1, a gene that triggers formation of these autophagosome structures.5
Beclin-1 dependent autophagy helps protect delicate mitochondria and
helped inhibit inflammation to support cardiovascular health in an
animal study.5 Our formula contains 10 mg of piperlongumine.
Take alone or with Senolytic Activator
While cellular housekeeping orchestrated by autophagy is a different
process than the ones that govern the removal of senescent cells, they
are complementary. Therefore, GEROPROTECT® Autophagy Renew can be taken
alone, or in conjunction with our Senolytic Activator formula.