Our new B12 Elite combines two types of cobalamin:
adenosylcobalamin and methylcobalamin. These are “active” forms—meaning
your body can make use of them right away.
Adenosylcobalamin helps preserve neuronal function
Leucine-Rich Repeat Kinase 2 (LRRK2) is a type of enzyme that modifies other proteins by adding phosphate groups.1 Inhibiting the activity of this enzyme has been associated with helping to preserve neuronal tissue.2
A series of preclinical studies has shown that the adenosylcobalamin
form of B12 can inhibit the activity of multiple LRRK2 variants in
neurons by decreasing phosphorylation (the addition of phosphate groups
to amino acids).3
These studies found that adenosylcobalamin helped regulate healthy
release of dopamine, a neurotransmitter that plays an important role in
cognitive functions such as motor control, arousal, reinforcement and
reward.3-6
A cofactor for energy metabolism
Adenosylcobalamin is active in the mitochondria, the powerhouses of
your cells. It’s required as a cofactor for the synthesis of
succinyl-CoA, a compound that supports cellular energy metabolism.7-9
Methylcobalamin for cellular health & beyond
Methylcobalamin is another neurologically active form of B12 (though
in different ways than adenosylcobalamin). Methylcobalamin supports the
central nervous system, and it’s essential for the replication and
growth of cells.10
Methylcobalamin helps to maintain already healthy homocysteine levels.11-14 Inhibiting excess levels of this compound is key to maintaining healthy cardiovascular and neurological function.
B12 for a healthy brain and more
This B12 formula combines methylcobalamin and adenosylcobalamin to
offer optimal cognitive support. Want the health benefits of the full
range of the B vitamins? We also offer our BioActive Complete B-Complex
formula: a wide-spectrum of B vitamins for whole-body health