levels decrease with age (~50% every 20 years) and these levels are
directly correlated with a number of age-related conditions and
neurodegenerative disease. A decline in NAD+ results in a decrease in
energy metabolism, weakened DNA repair, and inefficient immune
activation. Sirtuins, a class of longevity enzymes that regulate and
control genes rely on NAD+ to guide them to do their functions.
Consequently, as levels decline, sirtuins aren’t optimally guided to do
their jobs to repair and maintain the body for peak health and
performance. If there isn't enough NAD+ to guide sirtuins to maintain
cellular identity, skin cells start to act like nerve cells, nerve cells
start to act like kidney cells, etc. – the body is confused. This
explains why the body breaks down with old age and consequently wrinkles
appear, there will be less benefit from exercise, energy levels
decline, constant fatigue and compromised mitochondrial function occurs.