The Importance of NAD+
NAD+
(nicotinamide adenine dinucleotide) is a coenzyme that is found in all
living cells. It is important for a number of chemical reactions that
occur in the body, including energy metabolism, DNA repair, and the
regulation of enzyme activity. It is also involved in processes that
help to maintain the integrity of DNA, and it can help to regulate the
activity of certain enzymes that are involved in important biological
functions. As we age, the levels of NAD+ in our cells decline, which can
lead to a number of age-related diseases and conditions.
Maintaining healthy levels of NAD+ may help to reduce the risk of these diseases and promote overall health and well-being.
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NAD+ Declines with Aging
NAD+
levels decrease with age (~50% every 20 years) and these levels are
directly correlated with a number of age-related conditions and
neurodegenerative disease. A decline in NAD+ results in a decrease in
energy metabolism, weakened DNA repair, and inefficient immune
activation. Sirtuins, a class of longevity enzymes that regulate and
control genes rely on NAD+ to guide them to do their functions.
Consequently, as levels decline, sirtuins aren’t optimally guided to do
their jobs to repair and maintain the body for peak health and
performance. If there isn't enough NAD+ to guide sirtuins to maintain
cellular identity, skin cells start to act like nerve cells, nerve cells
start to act like kidney cells, etc. – the body is confused. This
explains why the body breaks down with old age and consequently wrinkles
appear, there will be less benefit from exercise, energy levels
decline, constant fatigue and compromised mitochondrial function occurs.
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Increase NAD+ with Cell Being
Cell
Being is a synergistic mix of molecules that support cellular energy to
promote DNA repair and maintain metabolic homeostasis by increasing
NAD+ levels. NMN is a precursor to NAD+, which means that it converts
into NAD+ in the cell. We paired NMN with trans-resveratrol because they
work synergistically to further enhance sirtuin activation, amplifying
the beneficial effects on cellular health. Then we added TMG to improve
methylation pathways to potentially avoid depleting methyl groups from
increased NAD+ production. It has also been used primarily to optimize
athletic performance and to improve heart health.